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What to Know About PRF and PRP Technologies for Hair Restoration

If you’ve tried other methods for hair restoration and found no success, it may be time to consider PRP or PRF treatments. Both hair loss treatments are based on regenerative medicine technologies and use injectable solutions that contain a high platelet concentration and growth factors for hair rejuvenation. But even if PRP and PRF injections are closely similar in terms of intended results, there are distinct differences between the two treatments.

So what’s the difference between PRP and PRF treatment? The main difference is that the method of preparation of PRF injections provides a higher concentration of platelets with additional stem cells, white blood cells, and fibrin from the blood. It has a more potent and rich hair growth solution which is why it’s considered more effective than the normal PRP injection. Your choice of hair loss treatment will depend on your needs and the extent of your condition.

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PRP vs. PRF for Hair Loss Treatment: What’s the Difference?

Hair loss is a common aesthetic problem that can be experienced by men and women. Most cases of hair loss are characterized by visible hair thinning and hair fall, but others occur with a receding hairline and the appearance of patchy spots. The latter symptoms are usually associated with the condition called androgenic alopecia.

If you have androgenetic alopecia or other forms of hair loss, you can benefit from PRP and PRF technologies for hair restoration. Instead of getting a hair transplant surgery to move hair into thinning or balding areas of the scalp, you can get minimally invasive PRP or PRF injections to stimulate dormant hair follicles and encourage new hair growth.

What are PRP and PRF Technologies for Hair Restoration 

Platelet rich plasma (PRP) and platelet-rich fibrin (PRF) therapy are popular forms of regenerative medicine. Both are considered autologous blood-derived cellular treatments that increase hair thickness and improve nutrients and blood supply to the hair follicle to encourage hair regrowth. They can also boost collagen production for faster tissue regeneration and new cell growth for the scalp and hair.

They can be used in combination with stem cell therapy for hair loss. But recently, PRP and PRF injections have also shown potential as independent hair restoration treatments. They are effective solutions for different kinds of hair loss, such as:

  • Androgenic alopecia (male or female pattern baldness)
  • Thinning hair from vitamin or iron deficiency
  • Telogen effluvium (severe hair loss caused by stress)
  • Alopecia areata (hair loss that happens as a result of the immune system attacking the follicles)
  • Cicatricial or scarring alopecia (hair loss caused by inflammation of the hair follicle and scalp) 

Comparing PRP vs PRF for Hair Restoration: 5 Key Differences

a man had PRP hair treatment in a clinic

To have a better idea of which injectable hair loss solution is compatible for you, it’s important to know the essential differences between PRP and PRF treatment. Here’s an overview of how PRP and PRF hair restoration therapy differ from each other:

1. What the Injections Contain

Generally, PRP and PRF injections contain platelet-rich plasma and various growth factors that are required for tissue healing and hair regeneration. However, PRP treatments contain an additional anticoagulant to help preserve the function and quality of the regenerative cells, as well as prevent early platelet activation. 

Meanwhile, PRF hair loss treatment doesn’t contain any additives, including anticoagulants. The PRF serum simply contains natural fibrin, which is a protein involved in blood clotting and various healing processes in the body. The injections also contain white blood cells, stem cells, cytokines, and other essential growth factors that can help in hair regrowth.

2. Amount of Platelet  

Autologous PRF injections can contain 10 times more platelets than PRP treatments, which typically have 2 to 5 times the number of platelets than normal blood. This is because the speed at which blood is centrifuged for PRF therapy is slower, which results in a layer of platelet-rich plasma with fibrin, white blood cells, and stem cells. It also has more healing factors than what can be found in a PRP injection.

3.  Method of Preparation 

Both PRP and PRF hair restoration treatments require drawing blood from the patient as the first step in serum preparation. Normally, providers will take a small blood sample from the arm, transfer it to a tube, and put it in a centrifuge machine. Depending on the type of serum being prepared, the speed at which blood is spun can also differ:

  • PRP therapy - may be spun at 2200 rpm to 3300 rpm for 10 minutes for the first spin to separate red blood cells and white blood cells, followed by a second spin done at 3600 rpm for 15 minutes to separate the platelet rich plasma from the platelet-poor plasma 
  • PRF therapy - the centrifuge speed can differ based on the type of PRF injection being prepared: advanced PRF (A-PRF) injections are spun at 1300 rpm for 14 minutes, advanced PRF plus (A-PRF+) uses the same 1300 rpm for 8 minutes, and injectable PRF (I-PRF) for hair loss is spun at 700 rpm for around 3 minutes

4.  Diffusion

Since PRP treatments are spun at a faster speed than PRF, its serum has a consistency that allows faster spread and release of platelets and growth factors at the treatment area. PRF injections have a fibrin matrix that acts as a scaffolding for the stem cells, platelets, and growth factors. 

For this reason, PRF has a slower release of proteins and healing factors once injected into the scalp which means that it can promote healing and tissue regeneration over a longer period of time.

5. Effectiveness     

Although PRP and PRF treatments are still relatively new, there are already several studies that back up their efficiency in promoting hair growth. With its higher platelet count and slower release of growth factor, PRF tends to be more effective and last longer than PRP for hair restoration.

One study shows that PRF injections can provide increased hair follicle counts and visible hair regrowth in a period of 3 to 6 months after treatment. Meanwhile, another study shares that most improvements from PRP therapy can be visible within 6 to 12 months after procedures. Although their results are long-lasting, you may still need to get a maintenance treatment to retain its effects. 

Safety of PRF vs PRP for Hair Loss 

PRF and PRP injections are safe treatment options for addressing the symptoms of hair loss. Since they’re autologous, there’s minimal risk of incurring an allergic reaction or other serious complications. They’re also unlikely to be rejected by the body since the injections contain your blood. In fact, they can boost the healing properties of the body and support your hair regeneration and its growth cycle.

The only possible side effects from PRP and PRF injections are temporary swelling, bruising, and scalp pain. You may also experience dizziness, headaches, and scalp irritation during the healing process.  

Reverse the Effects of Hair Loss With PRP Hair Restoration at Dr. V Medical Aesthetics  

Dr. V and her team

PRP and PRF are both advanced technologies that can help stimulate healthier hair growth. But in terms of effectiveness, PRF injections can perform better for hair restoration since they tend to have more platelets, stem cells, and growth factors. However, the decision on whether you should get PRP or PRF will depend on your needs and priorities.

At Dr. V Medical Aesthetics, we offer world-class hair loss solutions with PRP injections. We have a team of specialists who can administer safe and effective PRP hair restoration treatments. Call us today to learn more about PRP hair treatment and book your consultation to discuss your specific hair loss symptoms.


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