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Cagrilintide and Semaglutide: What You Need to Know

When thinking about weight loss, there are only 2 options that people widely accept as an authentic and effective solution, which are exercise and a healthy balanced diet. However, there are instances when obesity can’t simply be resolved with lifestyle changes. Therefore, complementary treatments and other supplements may sometimes be necessary.

So what are Cagrilintide and Semaglutide? Cagrilintide and Semaglutide are weight loss drugs that are combined to produce weight loss results for those whose obesity can’t be addressed by simple changes in lifestyle habits. Cagrilintide and Semaglutide can help you achieve baseline body weight and decreased fat mass.

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Cagrilintide and Semaglutide Combination for Weight Loss Treatments

An unpopular opinion is that obesity is actually a chronic metabolic disease instead of a mere result of poor lifestyle habits. Obesity can be caused by a variety of factors that aren't limited to your habits and consumption. There are cases when diabetes or hormonal irregularities are the sources of poor body weight management that led to obesity.

Because obesity is a disease, certain medications may be required for greater weight loss to reduce the risk of other diseases. Cagrilintide and Semaglutide are among the medications recommended to help people reduce total body weight through hormones by influencing food intake and weight loss mechanisms within the body.

Cagrilintide Plus Semaglutide for Obesity Management

Cagrilintide and Semaglutide are combined to address obesity, but this treatment doesn’t always work because it still depends on your body’s response to the combined drugs. Despite that, when your body does respond to this treatment, substantial weight loss can be experienced. 

The phase 2 clinical trial of a research study shows that Cagrilintide is often combined with 2.4mg of Semaglutide for enhanced effectiveness. Additionally, Novo Nordisk is currently developing this specific drug combination, which is known as CagriSema. 

Both kinds of weight loss drugs have an effect on Type 2 diabetes, but for further clarification on the purpose of each drug, below is a table for a better understanding of why they are combined to reduce weight gain and achieve greater weight loss.

Weight Loss MedicationContentsPurpose
CagrilintideLong-acting novel amylin analog that antagonizes endogenous amylin and calcitonin receptors.Developed by Novo Nordisk for the treatment of type 2 diabetes and obesity. This medication is well-tolerated by overweight and obese people, leading to significantly reduced body weight.
SemaglutideGlucagon-like peptide-1 (GLP 1 receptor agonist)Semaglutide is a hormone-based anti-obesity medication that’s designed to affect your appetite by making you feel fuller. It mostly aims to affect brain signals to influence your bodily reaction to food and change your consumption habits.

Semaglutide and Cagrilintide For Non-Diabetics

A research study has found that Semaglutide and Cagrilintide drug combination can also be effective for off-label use to help individuals reduce body weight. This combination is more effective if accompanied by a lifestyle intervention plan that includes a healthy, low-calorie diet and regular exercise. As of writing, Cagrilintide and Semaglutide are still undergoing clinical trial investigations on their actual impact on weight management.

Eligibility for Cagrilintide and Semaglutide Combination 

Both Cagrilintide and Semaglutide are used to treat or manage type 2 diabetes. Although they are authorized and effective for off-label body weight loss management uses, this drug combination isn’t recommended for people who have type 1 diabetes.

It’s necessary to consult with your healthcare provider regarding your eligibility to have this drug combination. This is especially important if you’re taking other treatments for type 2 diabetes (e.g, SGLT2 inhibitor) simultaneously with these weight loss drugs.

Effectiveness of Cagrilintide Novo Nordisk with Semaglutide

cagrilintide and semaglutide what you need to know

Combining Cagrilintide with Semaglutide 2.4mg can enhance its effectiveness. You may also want to take note of the following:

  • Avoid alcohol. Alcohol consumption can have a severe negative effect on your glucose level, which can cause adverse events if done simultaneously with the treatment. The combined weight loss drugs produce insulin for high levels of blood sugar, so if alcohol will produce the same effect then it can produce an adverse event such as extremely low blood sugar.
  • Don’t take other medications that can cause contraindications. These medications can include aspirin, or medicines to control food intake. You can prevent the intake of medications that can interfere with the effectiveness of the treatment by discussing with your doctor any possible medications that you’ll have during the course of your treatment.

Furthermore, to reduce total body weight, the goal of these weight loss drugs isn’t just to eliminate excess weight but to reduce weight gain as well.

Recommended Cagrilintide Novo Nordisk with Semaglutide Dosage

The target dose of these weight loss drugs takes into consideration the target fat mass to be reduced. Cagrilintide is often recommended with 2.4mg Semaglutide, but this can vary depending on a patient’s need.

Some patients may be prescribed multiple doses for efficient weight reduction. A doctor may prescribe a target dose, or you can follow the indications placed on the label for oral Semaglutide and Cagrilintide doses. These weight loss drugs can also be applied through subcutaneous injection.

The target dose may be recommended based on your target total body weight. Your personal information and medical history can be considered by your healthcare provider for an effective weight reduction treatment plan.

In case you miss a dose of medicine, you can simply take it as soon as possible. Do not double dose, so that means that if it’s almost time for your next dosage, you should simply follow the original schedule of your next dose. For prolonged missed dosage, consult your doctor so you can restart treatment.

Side Effects of Semaglutide and Cagrilintide

All medications may cause unwanted adverse events, which means that you may still be prone to adverse effects even after the correct intake of Semaglutide and Cagrilintide. Some of these adverse events can include:

  • Diarrhea or constipation
  • Hair loss
  • Heartburn
  • Belching
  • Bloating
  • Fever
  • Gaseous stomach pain
  • Yellow eyes or skin

How Semaglutide and Cagrilintide Affect Perception of Obesity

People have a misconception that natural remedies are the only way to beat obesity but doing so will deprive an individual of a chance at an effective treatment that can improve overall health.

Semaglutide and Cagrilintide medication treats obesity as the chronic metabolic disease that it is, therefore providing a better healing environment that can encourage individuals with obesity to dedicate themselves to the treatment.

This combination of weight loss drugs eliminates the stigma of obesity as a result of poor lifestyle habits and perceives it as a disease that requires holistic treatment. Weight loss drugs also offer speedy treatment results so the risk of developing cardiovascular disease and other diseases associated with weight gain or excess weight can also be reduced because of faster achievement of baseline body weight.

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Dr. V

Cagrilintide and Semaglutide are an effective combination for greater weight loss reduction of people who have obesity that can’t simply be resolved with changes in lifestyle habits. These anti-obesity medications recognize the fact that obesity isn’t just caused by unhealthy choices and food consumption.

Obesity is caused by a wide range of factors, which can only be accurately diagnosed and treated by a qualified healthcare provider. If you’re looking for a healthcare provider that can provide an effective treatment plan to reduce excess weight, reach out to us for appropriate weight management.

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